brd4 bd1 bd2 gst tag (BPS Bioscience)

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BPS Bioscience brd4 bd1 bd2 gst tag
Brd4 Bd1 Bd2 Gst Tag, supplied by BPS Bioscience, used in various techniques. Bioz Stars score: 93/100, based on 9 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/brd4+(bd2)%2C+gst-tag+recombinant/BRD4+(BD1%2BBD2)%2C+GST-Tag+Recombinant/pm39764880-299-5-8
Average 93 stars, based on 9 article reviews

brd4 bd1 bd2 gst tag - by Bioz Stars, 2026-10

93/100 stars

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Inhibition:

Article Title: Discovery of 4,5-dihydro-benzo[g]indazole-based hydroxamic acids as HDAC3/BRD4 dual inhibitors and anti-tumor agents.
Article Snippet: Concurrent inhibition of HDAC and BRD4, two well-established epigenetic targets for anti-tumor therapy, demonstrates the potential to enhance anti-tumor effects synergistically.. The present study involves the development of a series of novel HDAC3/BRD4 dual inhibitors, followed by evaluation of their antitumor efficacy against several tumor models.. Guided by scaffold hopping strategy, key pharmacophore of BRD4 inhibitor I-BET151 was incorporated into an in-house developed HDAC3-selective inhibitor 17h.

Recombinant:

Article Title: Tiny Titans ‐ Nanobodies as Powerful Tools for TR‐FRET Assay Development
Article Snippet: .. Determination of equilibrium dissociation constant (KD) of JQ1FITC toward individual recombinant bromodomains and KD,app toward endogenous BRD4 in HEK293T lysate: Recombinant BRD4(BD1) and BRD4(BD2) were purchased from BPS Biosciences, Inc and Epicypher, Inc (GST-BRD4(BD1), 31040; GST-BRD4(BD2), 15– 0013, respectively). ..

Article Title: Epigenetic modulation through BET bromodomain inhibitors as a novel therapeutic strategy for progranulin-deficient frontotemporal dementia.
Article Snippet: .. Recombinant BRD4(BD1) and BRD4(BD2) were purchased from BPS Biosciences, Inc and Epicypher, Inc (GST-BRD4(BD1), 31,040; GST-BRD4(BD2), 15–0013, respectively). .. Recombinant bromodomains were diluted to 0.5 nM in assay buffer (25 mM HEPES, 150 mM NaCl, 0.5 mg/mL BSA, 0.005% TWEEN-20, pH 7.5) with 2 nM CoraFluor-1-labeled GST VHH (ChromoTek ST-250), then JQ1-FITC was added in serial dilution (cmax = 100 nM) using an HP D300 digital dispenser and allowed to equilibrate for 2 h at room temperature before TR-FRET measurements were taken.

Article Title: Epigenetic modulation through BET bromodomain inhibitors as a novel therapeutic strategy for progranulin-deficient frontotemporal dementia
Article Snippet: .. Recombinant BRD4(BD1) and BRD4(BD2) were purchased from BPS Biosciences, Inc and Epicypher, Inc (GST-BRD4(BD1), 31,040; GST-BRD4(BD2), 15–0013, respectively). .. Recombinant bromodomains were diluted to 0.5 nM in assay buffer (25 mM HEPES, 150 mM NaCl, 0.5 mg/mL BSA, 0.005% TWEEN-20, pH 7.5) with 2 nM CoraFluor-1-labeled GST V H H (ChromoTek ST-250), then JQ1-FITC was added in serial dilution (c max = 100 nM) using an HP D300 digital dispenser and allowed to equilibrate for 2 h at room temperature before TR-FRET measurements were taken.

other:

Article Title: Fused pyrimidine compounds as BRD4 and JAK2 dual inhibitors and methods for use thereof
Article Snippet: Biotinylated substrate (Acetylated histone H4, biotinylated substrate—cat no. AS64989-025, Anaspec) stock and FAC Enzyme Sub-Stock concentration in μM FAC in nM BRD4-BD1 36.65 25 BRD4-BD2 36.65 50 BRD2-BD1 36.65 50 BRD3-BD!

Article Title: Thalidomide derivatives degrade BCL-2 by reprogramming the binding surface of CRBN
Article Snippet: CRBN-FLAG (no. 100329) and BRD4-GST (no. 31044) were purchased from BPS Bioscience.

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brd4 bd1 bd2 gst tag (BPS Bioscience)

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